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Methylprednisolone

甲基潑尼松龍

Mechanism of action:

Methylprednisolone 是一種合成型糖皮質類固醇（synthetic glucocorticoid）。Methylprednisolone 為脂溶性分子，可自由穿過細胞膜，在細胞質中與糖皮質激素受體（glucocorticoid receptor）結合後，形成配體-受體複合體，並移動進入細胞核，上調抗發炎基因（如 annexin A1）的表達量；抑制促發炎基因（如 IL-1、IL-2、IL-6、TNF-α）的表達量。

​Reference(s):

1. Szefler SJ et al. (1986). Methylprednisolone versus prednisolone pharmacokinetics in relation to dose in adults. Eur J Clin Pharmacol. 


2. Abboud R et al. (2017). Interaction of glucocorticoids and progesterone derivatives with human serum albumin. Chem Phys Lipids. 


3. Matabosch X et al. (2013). Urinary profile of methylprednisolone and its metabolites after oral and topical administrations. J Steroid Biochem Mol Biol.

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