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The Sound of Evolution
Minoxidil
米諾地爾
Mechanism of action:
Minoxidil 是一種吡啶類（pyrimidine）衍生物。Minoxidil 的詳細機制尚未明確，但已知會使 ATP 敏感型鉀離子通道（ATP-sensitive potassium channel）開啟，讓血管平滑肌超極化，血管擴張。有研究指出 minoxidil 會促進真皮乳頭細胞（dermal papilla cell）增殖，抑制細胞凋亡訊號。
Reference(s):
Olsen EA et al. (2007). A multicenter, randomized, placebo-controlled, double-blind clinical trial of a novel formulation of 5% minoxidil topical foam versus placebo in the treatment of androgenetic alopecia in men. J Am Acad Dermatol.
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