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Nedocromil

萘多羅米
Mechanism of action:
Nedocromil 是一種色原酮類(chromone)衍生物。Nedocromil 可抑制肥大細胞(mast cell)的去顆粒作用(degranulation),阻止釋放組織胺(histamine)、白三烯(leukotrienes)、前列腺素(prostaglandin)等發炎介質。
Reference(s):
1. Monteseirin J et al. (2005). L-selectin expression on neutrophils from allergic patients. Clin Exp Allergy.
2. Yazid S et al. (2010). Antiallergic cromones inhibit neutrophil recruitment onto vascular endothelium via annexin-A1 mobilization. Arterioscler Thromb Vasc Biol.
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