top of page
< Back

Octreotide

奧曲肽

Mechanism of action:

Octreotide 是一種合成體抑素（somatostatin）類似物，屬於環狀八胜肽（cyclic octapeptide）。Octreotide 能活化體抑素受體（somatostatin receptors），特別是 SSTR2 與 SSTR5 親和力最高。當體抑素受體活化後，會抑制腺苷酸環化酶（adenylyl cyclase），使 cAMP 濃度下降，抑制生長激素、胰島素、升糖素、胃泌素、胰泌素等激素的釋放。

​Reference(s):

1. Biermasz NR et al. (2017). New medical therapies on the horizon: oral octreotide. Pituitary. 


2. Battershill PE et al. (1989). Octreotide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in conditions associated with excessive peptide secretion. Drugs. 


3. Prelevic GM et al. (1990). Inhibitory effect of sandostatin on secretion of luteinising hormone and ovarian steroids in polycystic ovary syndrome. Lancet.

bottom of page