top of page
Omalizumab
奧馬珠單抗
Mechanism of action:
Omalizumab 是一種抗 IgE 抗體的 IgG1 單株抗體(anti-IgE IgG1 monoclonal antibody)。Omalizumab 能專一性結合 IgE 抗體的 Cε3 區域,阻止 IgE 抗體與肥大細胞(mast cell)或嗜鹼性球(basophil)上的 FcεRI 受體結合,抑制誘發過敏反應。
Reference(s):
1. Jensen RK et al. (2015). Structure of the omalizumab Fab. Acta Crystallogr F Struct Biol Commun.
2. Kaplan AP et al. (2008). Treatment of chronic autoimmune urticaria with omalizumab. J Allergy Clin Immunol.
bottom of page
