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The Sound of Evolution
Oprelvekin
重組白血球介素-11
Mechanism of action:
Oprelvekin 是一種重組的人類介白素-11（recombinant human interleukin-11）。Oprelvekin 能與巨核細胞前驅細胞（megakaryocyte progenitor）上的 IL-11 受體 α（IL-11Rα）結合，進一步吸引 gp130 輔助受體，形成訊號傳遞複合體，啟動 JAK1/JAK2 訊號路徑，使 STAT3 磷酸化進入細胞核，誘導與造血相關基因的表達，使巨核細胞前驅細胞增殖、分化與成熟，促進血小板產生。
Reference(s):
1. Nandurkar HH et al. (1998). The role of IL-II in hematopoiesis as revealed by a targeted mutation of its receptor. Stem Cells.
2. Li R et al. (2001). Cloning of rat interleukin 11 and interleukin 11 receptor alpha chain and analysis of their expression in rat uterus in the peri-implantation period. Reproduction.
3. Nandurkar HH et al. (1996). The human IL-11 receptor requires gp130 for signalling: demonstration by molecular cloning of the receptor. Oncogene.
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