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The Sound of Evolution
Oxazepam
奧沙西泮
Mechanism of action:
Oxazepam 是一種苯二氮平類（benzodiazepine）衍生物。Oxazepam 結合於中樞神經系統 GABA_A 受體上的苯二氮平結合位點，以增強 GABAergic 的抑制作用。當 GABA 與這些受體結合時，氯離子（Cl⁻）通道開啟，使神經元膜超極化（hyperpolarization），導致神經元興奮性下降，降低邊緣系統與大腦皮質的過度活化。
Reference(s):
1. Peppers MP et al. (1996). Benzodiazepines for alcohol withdrawal in the elderly and in patients with liver disease. Pharmacotherapy.
2. Skerritt JH et al. (1983). Enhancement of GABA binding by benzodiazepines and related anxiolytics. Eur J Pharmacol.
3. Oelschlager H et al. (1989). [Chemical and pharmacologic aspects of benzodiazepines]. Schweiz Rundsch Med Prax.
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