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The Sound of Evolution
Pirbuterol
吡布特羅
Mechanism of action:
Pirbuterol 是一種選擇性 β₂-腎上腺素受體促效劑（selective β₂-adrenergic agonist）。Pirbuterol 能活化支氣管平滑肌的 β₂ 受體，透過 Gs 蛋白偶聯活化腺苷酸環化酶（adenylate cyclase），使 cAMP 濃度上升，進而活化蛋白激酶 A（protein kinase A），最終使支氣管平滑肌放鬆，產生支氣管擴張。
Reference(s):
1. Carie AE et al. (2007). A chemical biology approach identifies a beta-2 adrenergic receptor agonist that causes human tumor regression by blocking the Raf-1/Mek-1/Erk1/2 pathway. Oncogene.
2. Leier CV et al. (1982). Intravenous pirbuterol. Clin Pharmacol Ther.
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