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The Sound of Evolution
Prucalopride
普卡必利
Mechanism of action:
Prucalopride 是一種高度選擇性 5-HT₄ 受體促效劑（selective serotonin 5-HT₄ receptor agonist）。Prucalopride 會與腸肌神經叢（myenteric plexus）上的 5-HT₄ 受體結合，啟動 Gs 蛋白，進而活化腺苷酸環化酶（adenylyl cyclase），使 cAMP 上升，促進腸道神經末梢釋放乙醯膽鹼（acetylcholine），增強副交感神經對腸道平滑肌的刺激，使腸道蠕動增強，高幅度推進性收縮增加。
Reference(s):
1. Shin A et al. (2014). Systematic review with meta-analysis: highly selective 5-HT4 agonists (prucalopride, velusetrag or naronapride) in chronic constipation. Aliment Pharmacol Ther.
2. Omer A et al. (2017). An update on prucalopride in the treatment of chronic constipation. Therap Adv Gastroenterol.
3. Briejer MR et al. (2001). The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound. Eur J Pharmacol.
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