top of page
< Back

Pyridostigmine

吡斯的明

Mechanism of action:

Pyridostigmine 是一種乙醯膽鹼酯酶抑制劑（acetylcholinesterase inhibitor），屬於胺基甲酸酯類（carbamate）衍生物。Pyridostigmine 會與乙醯膽鹼酯酶（acetylcholinesterase）的活性位點結合，使乙醯膽鹼酯酶暫時失去分解乙醯膽鹼（acetylcholine）的能力，使突觸間隙的乙醯膽鹼濃度增加，增強神經肌肉接合處的訊號傳遞。

​Reference(s):

1. Singer W et al. (2003). Acetylcholinesterase inhibition: a novel approach in the treatment of neurogenic orthostatic hypotension. J Neurol Neurosurg Psychiatry. 


2. Gilhus NE et al. (2015). Myasthenia gravis: subgroup classification and therapeutic strategies. Lancet Neurol. 


3. Rodriguez Cruz PM et al. (2018). The Neuromuscular Junction and Wide Heterogeneity of Congenital Myasthenic Syndromes. Int J Mol Sci.

bottom of page