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Ramelteon

雷美替胺

Mechanism of action:

Ramelteon 是一種選擇性褪黑激素受體促效劑（selective melatonin receptor agonist）。Ramelteon 能活化下視丘的視交叉上核（suprachiasmatic nucleus）的 MT₁ 與 MT₂ 褪黑激素受體（melatonin receptor）。MT₁ 受體負責促進入睡、抑制清醒訊號；MT₂ 負責調整與同步晝夜節律（circadian rhythm）。

​Reference(s):

1. Karim A et al. (2006). Disposition kinetics and tolerance of escalating single doses of ramelteon, a high-affinity MT1 and MT2 melatonin receptor agonist indicated for treatment of insomnia. J Clin Pharmacol. 


2. Miyamoto M et al. (2009). Pharmacology of ramelteon, a selective MT1/MT2 receptor agonist: a novel therapeutic drug for sleep disorders. CNS Neurosci Ther.

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