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Rasagiline

雷沙吉蘭

Mechanism of action:

Rasagiline 是一種選擇性單胺氧化酶 B 抑制劑（selective monoamine oxidase-B inhibitor）。單胺氧化酶 B（monoamine oxidase-B）是負責在腦內分解多巴胺（dopamine）的主要酵素之一。Rasagiline 與單胺氧化酶 B 共價結合後，使其酵素失去活性，導致神經突觸間隙的多巴胺濃度上升，增強多巴胺訊號在紋狀體（striatum）中的作用。

​Reference(s):

1. Weinreb O et al. (2010). Rasagiline: a novel anti-Parkinsonian monoamine oxidase-B inhibitor with neuroprotective activity. Prog Neurobiol. 


2. Leegwater-Kim J et al. (2010). The role of rasagiline in the treatment of Parkinson's disease. Clin Interv Aging. 


3. Chen JJ et al. (2007). Comprehensive review of rasagiline, a second-generation monoamine oxidase inhibitor, for the treatment of Parkinson's disease. Clin Ther.

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