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The Sound of Evolution
Ropivacaine
羅哌卡因
Mechanism of action:
Ropivacaine 主要作用於阻斷神經細胞膜上的電壓門控鈉離子通道（voltage-gated Na⁺ channels）。Ropivacaine 在未離子化狀態下可穿越神經細胞膜，進入神經元內部後再轉為離子化型態，結合於鈉離子通道的內側結合位點，尤其偏好開啟或失活狀態（open/inactivated state）的通道，使鈉離子無法內流，神經細胞膜無法去極化（depolarization），導致動作電位無法產生與向前傳導。
Reference(s):
1. Liu BG et al. (2000). The effects of ropivacaine on sodium currents in dorsal horn neurons of neonatal rats. Anesth Analg.
2. Arlander E et al. (1998). Metabolism of ropivacaine in humans is mediated by CYP1A2 and to a minor extent by CYP3A4: an interaction study with fluvoxamine and ketoconazole as in vivo inhibitors. Clin Pharmacol Ther.
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