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The Sound of Evolution
Saxagliptin
沙格列汀
Mechanism of action:
Saxagliptin 是一種二肽基肽酶-4 抑制劑（dipeptidyl peptidase-4 inhibitor）。二肽基肽酶-4（DPP-4）是一種負責分解腸泌素的酵素，腸泌素比如胰高血糖素樣肽-1（glucagon-like peptide-1）和葡萄糖依賴性促胰島素多肽（glucose-dependent insulinotropic polypeptide）等。當 saxagliptin 抑制二肽基肽酶-4 後，使腸泌素不易被分解，在血中濃度與作用時間延長，能促進胰島 β 細胞分泌胰島素；抑制胰島 α 細胞分泌升糖素（glucagon）。
Reference(s):
1. Rosenstock J et al. (2008). Glucose-lowering activity of the dipeptidyl peptidase-4 inhibitor saxagliptin in drug-naive patients with type 2 diabetes. Diabetes Obes Metab.
2. Metzler WJ et al. (2008). Involvement of DPP-IV catalytic residues in enzyme-saxagliptin complex formation. Protein Sci.
3. Crepaldi G et al. (2007). Dipeptidyl peptidase 4 (DPP-4) inhibitors and their role in Type 2 diabetes management. J Endocrinol Invest.
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