top of page
The Sound of Evolution
Terbutaline
特布他林
Mechanism of action:
Terbutaline 是一種選擇性 β₂-腎上腺素受體促效劑（selective β₂-adrenergic agonist）。Terbutaline 能活化支氣管或子宮平滑肌的 β₂ 受體，透過 Gs 蛋白偶聯活化腺苷酸環化酶（adenylate cyclase），使 cAMP 濃度上升，進而活化蛋白激酶 A（protein kinase A），最終使支氣管或子宮平滑肌放鬆。
Reference(s):
1. Rhodes MC et al. (2004). Terbutaline is a developmental neurotoxicant: effects on neuroproteins and morphology in cerebellum, hippocampus, and somatosensory cortex. J Pharmacol Exp Ther.
2. Hochhaus G et al. (1992). Pharmacokinetic/pharmacodynamic characteristics of the beta-2-agonists terbutaline, salbutamol and fenoterol. Int J Clin Pharmacol Ther Toxicol.
3. Haahtela T et al. (1991). Comparison of a beta 2-agonist, terbutaline, with an inhaled corticosteroid, budesonide, in newly detected asthma. N Engl J Med.
bottom of page