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Torsemide

托拉塞米

Mechanism of action:

Torsemide 是一種袢利尿劑（loop diuretic），屬於磺醯尿素類（sulfonylurea）衍生物。在腎臟的亨耳氏套（Henle's loop）的升支粗段（thick ascending limb），存在 Na⁺-K⁺-2Cl⁻ 共轉運體（Na⁺/K⁺/2Cl⁻ cotransporter），負責將這三種離子由腎小管腔運入管壁細胞。Torsemide 能與此轉運體蛋白結合，抑制 Na⁺、K⁺、Cl⁻ 的重新吸收，使鈉與水分排出增加，並影響體液量與血壓調控。

​Reference(s):

1. Lopez B et al. (2008). Myocardial fibrosis in chronic kidney disease: potential benefits of torasemide. Kidney Int Suppl. 


2. Li XM et al. (2013). Could torasemide be a prophylactic agent of contrast induced acute kidney injury? A review about this field. Eur Rev Med Pharmacol Sci. 


3. Buggey J et al. (2015). A reappraisal of loop diuretic choice in heart failure patients. Am Heart J.

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