top of page
The Sound of Evolution
Xylometazoline
賽洛唑啉
Mechanism of action:
Xylometazoline 是一種 α-腎上腺素受體促效劑（α-adrenergic agonist）。Xylometazoline 主要活化鼻黏膜血管平滑肌上的 α₁-腎上腺素受體（Gq/11 蛋白偶聯受體），並對 α₂ 受體（Gi/o 蛋白偶聯受體）具有一定活性，使鼻黏膜血管平滑肌收縮，讓鼻黏膜血流量下降，組織水腫與充血減輕，鼻腔通氣阻力降低。
Reference(s):
1. Haenisch B et al. (2010). Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline. Fundam Clin Pharmacol.
2. Eccles R et al. (2008). The nasal decongestant effect of xylometazoline in the common cold. Am J Rhinol.
bottom of page