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The Sound of Evolution
Acamprosate
阿坎酸鈣
Mechanism of action:
Acamprosate 的確切機制尚不清楚。在中樞神經中，可能與麩胺酸（glutamate）以及 GABA 的神經傳導系統有交互作用，調整 glutamatergic 與 GABAergic 系統的動態平衡，此調節機制被認為與酒精依賴相關的中樞神經適應性變化有關。
Reference(s):
Antonescu IE et al. (2020). Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions. Pharmaceutics.
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