The Sound of Evolution
Acarbose
醣祿
Mechanism of action:
Acarbose 與小腸絨毛上的 α-glucosidase 做可逆的競爭性抑制。α-glucosidase 原本負責將腸道內的碳水化合物分解為葡萄糖，以便腸道吸收。當 acarbose 與 α-glucosidase 結合後，酵素被暫時抑制，使碳水化合物的分解變慢，進而延遲葡萄糖的吸收。
Reference(s):
1. Salehi A et al. (2001). TPN-evoked dysfunction of islet lysosomal activity mediates impairment of glucose-stimulated insulin release. Am J Physiol Endocrinol Metab.
2. Zhang H et al. (2006). Comparison of maltose and acarbose as inhibitors of maltase-glucoamylase activity in assaying acid alpha-glucosidase activity in dried blood spots for the diagnosis of infantile Pompe disease. Genet Med.
3. Gelb MH et al. (2006). Direct multiplex assay of enzymes in dried blood spots by tandem mass spectrometry for the newborn screening of lysosomal storage disorders. J Inherit Metab Dis.