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Acenocoumarol

醋硝香豆素
Mechanism of action:
Acenocoumarol 透過抑制肝臟中維生素 K 環氧還原酶(vitamin K epoxide reductase)的活性,阻斷維生素 K 的再生,進而抑制凝血因子 II、VII、IX、X 的合成,降低血液凝固能力。
Reference(s):
Saraeva RB et al. (2007). Pharmacogenetics of acenocoumarol: CYP2C9, CYP2C19, CYP1A2, CYP3A4, CYP3A5 and ABCB1 gene polymorphisms and dose requirements. J Clin Pharm Ther.
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