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The Sound of Evolution
Adalimumab
阿達木單抗
Mechanism of action:
Adalimumab 是一種與腫瘤壞死因子α（tumor necrosis factor-α，TNF-α）結合的單株抗體。TNF-α 是一種在慢性發炎反應中扮演關鍵角色的細胞激素，能促進發炎細胞活化與組織破壞。Adalimumab 阻斷 TNF-α 與其受體（TNFR1、TNFR2）的結合後，可抑制發炎的串級反應。
Reference(s):
1. Lorenz HM et al. (2002). Technology evaluation: adalimumab, Abbott laboratories. Curr Opin Mol Ther.
2. Flendrie M et al. (2003). Survival during treatment with tumour necrosis factor blocking agents in rheumatoid arthritis. Ann Rheum Dis.
3. Aguillon JC et al. (2003). New immunological weapons for medicine in the 21st Century: biological therapy based on the use of the latest generation monoclonal antibodies. Rev Med Chil.
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