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Ambenonium

安貝銨

Mechanism of action:

Ambenonium 是一種可逆性乙醯膽鹼酯酶抑制劑（reversible acetylcholinesterase inhibitor）。Ambenonium 會抑制神經突觸間隙中乙醯膽鹼酯酶（AChE）的活性，使乙醯膽鹼（ACh）在神經肌肉接合處的濃度上升並延長其作用時間。

​Reference(s):

1. Yamamoto K et al. (1991). Pharmacokinetics of ambenonium, a reversible cholinesterase inhibitor, in rats. Biopharm Drug Dispos. 


2. Komloova M et al. (2011). Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors—implications for early myasthenia gravis treatment. Bioorg Med Chem Lett. 


3. Liu T et al. (2025). BindingDB in 2024: a FAIR knowledgebase of protein-small molecule binding data. Nucleic Acids Res.

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