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Amikacin

阿米卡星

Mechanism of action:

Amikacin 能與細菌的 30S 核糖體亞基結合，干擾起始複合體（initiation complex）的形成，並導致 mRNA 誤讀與蛋白質合成受抑制。

Reference(s):

Tolmasky ME et al. (2000). Bacterial resistance to aminoglycosides and beta-lactams: the Tn1331 transposon paradigm. Front Biosci.

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