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Amoxicillin

阿莫西林

Mechanism of action:

Amoxicillin 會與細菌細胞膜上的青黴素結合蛋白（penicillin-binding proteins，PBPs）結合，阻斷轉肽酶（transpeptidase）反應，使肽聚醣（peptidoglycan）鏈無法交聯，導致細胞壁結構失去完整性，使細菌在滲透壓差作用下發生溶解而死亡。

​Reference(s):

1. Jariyawat S et al. (1999). The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1. J Pharmacol Exp Ther. 


2. Li M et al. (2006). Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters. Drug Metab Dispos.

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