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Arformoterol

阿福特羅

Mechanism of action:

Arformoterol 是一種選擇性 β₂-腎上腺素受體促效劑（long-acting β₂-adrenergic receptor agonist）。Arformoterol 會與支氣管平滑肌細胞膜上的 β₂-腎上腺素受體結合，活化腺苷酸環化酶（adenylyl cyclase），增加細胞內 cAMP 濃度，接著活化蛋白激酶 A（PKA），讓細胞質的 Ca²⁺ 濃度下降，促進平滑肌鬆弛。最終導致支氣管平滑肌鬆弛與支氣管擴張。

​Reference(s):

1. Somers GI et al. (2007). A comparison of the expression and metabolizing activities of phase I and II enzymes in freshly isolated human lung parenchymal cells and cryopreserved human hepatocytes. Drug Metab Dispos. 


2. Zhang M et al. (2000). Stereoselective glucuronidation of formoterol by human liver microsomes. Br J Clin Pharmacol.

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