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Atropine

阿托品

Mechanism of action:

Atropine 是一種非選擇性毒蕈鹼型乙醯膽鹼受體（muscarinic acetylcholine receptors）拮抗劑，可競爭性阻斷所有亞型（M₁ 至 M₅）受體上的乙醯膽鹼作用，導致副交感神經抑制。可導致心跳加快、瞳孔散大、支氣管平滑肌鬆弛、黏液分泌減少、平滑肌蠕動減弱、胃酸分泌下降、膀胱逼尿肌鬆弛、排尿抑制、口乾、皮膚乾燥、體溫上升等狀態。

​Reference(s):

1. Buels KS et al. (2012). Muscarinic receptor antagonists: effects on pulmonary function. Handb Exp Pharmacol. 


2. Kanto J et al. (1988). Pharmacokinetic implications for the clinical use of atropine, scopolamine and glycopyrrolate. Acta Anaesthesiol Scand.

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