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The Sound of Evolution
Benznidazole
苯乙咪唑
Mechanism of action:
Benznidazole 是一種硝基咪唑類（nitroimidazole）衍生物，作用於克氏錐蟲（Trypanosoma cruzi）等原蟲。Benznidazole 在克氏錐蟲細胞中會被硝基還原酶（nitroreductase）活化，形成硝基自由基（nitro radicals），這些自由基會與克氏錐蟲的 DNA、RNA 及蛋白質結合，造成這些分子受到破壞，引起寄生蟲生存受損並導致死亡。
Reference(s):
1. Maya JD et al. (2007). Mode of action of natural and synthetic drugs against Trypanosoma cruzi and their interaction with the mammalian host. Comp Biochem Physiol A Mol Integr Physiol.
2. Rajao MA et al. (2014). Unveiling benznidazole's mechanism of action through overexpression of DNA repair proteins in Trypanosoma cruzi. Environ Mol Mutagen.
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