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Bisacodyl

比沙可啶

Mechanism of action:

Bisacodyl 是一種二苯甲烷（diphenylmethane）的衍生物。Bisacodyl 在腸道中被腸道菌轉化為活性代謝物 bis-(p-hydroxyphenyl)-pyridyl-2-methane（BHPM）後，會透過尚不明確的路徑刺激腸肌神經叢（myenteric plexus），促進腸道平滑肌收縮與腸蠕動增加。同時可能促進腸上皮細胞的腺苷酸環化酶（adenylate cyclase）的活化，增加 cAMP，導致增加分泌黏液與排出氯離子（Cl⁻），並抑制 Na⁺ 與水分吸收，使糞便含水量上升、體積增大，增加排便相關反射的誘發可能性。

​Reference(s):

1. Kudo K et al. (1998). Laxative poisoning: toxicological analysis of bisacodyl and its metabolite in urine, serum, and stool. J Anal Toxicol. 


2. Roth W et al. (1988). Pharmacokinetics and laxative effect of bisacodyl following administration of various dosage forms. Arzneimittelforschung. 


3. Manabe N et al. (2009). Effects of bisacodyl on ascending colon emptying and overall colonic transit in healthy volunteers. Aliment Pharmacol Ther.

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