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The Sound of Evolution
Bisoprolol
比索洛爾
Mechanism of action:
Bisoprolol 是一種選擇性 β₁-腎上腺素受體阻斷劑（selective β₁-adrenergic receptor blocker）。Bisoprolol 主要阻斷心肌與竇房結上的 β₁ 受體，使心跳減慢、收縮力降低，減少心臟耗氧量、降低心輸出量。Bisoprolol 也能阻斷腎臟的鄰腎小球細胞 β₁ 受體，讓腎素釋放減少，導致腎素-血管張力素-醛固酮系統（RAAS）活性下降，進而影響血壓調控。
Reference(s):
1. Lancaster SG et al. (1988). Bisoprolol: A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in hypertension and angina pectoris. Drugs.
2. Ishiguro H et al. (2008). Antiarrhythmic effect of bisoprolol, a highly selective beta1-blocker, in patients with paroxysmal atrial fibrillation. Int Heart J.
3. Metra M et al. (2007). Bisoprolol in the treatment of chronic heart failure: from pathophysiology to clinical pharmacology and trial results. Ther Clin Risk Manag.
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