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Bupropion

安非他酮

Mechanism of action:

Bupropion 是正腎上腺素-多巴胺回收抑制劑（norepinephrine-dopamine reuptake inhibitor）。它可阻斷神經突觸前膜上的正腎上腺素轉運體（norepinephrine transporter）與多巴胺轉運體（dopamine transporter）的回收功能，使突觸間正腎上腺素與多巴胺濃度上升，進而影響注意力、情緒與成癮相關神經迴路的神經傳導。

​Reference(s):

1. Fryer JD et al. (1999). Noncompetitive functional inhibition at diverse, human nicotinic acetylcholine receptor subtypes by bupropion, phencyclidine, and ibogaine. J Pharmacol Exp Ther. 


2. Fava M et al. (2005). 15 years of clinical experience with bupropion HCl: from bupropion to bupropion SR to bupropion XL. Prim Care Companion J Clin Psychiatry.

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