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The Sound of Evolution
Carbenicillin
羧苄西林
Mechanism of action:
Carbenicillin 是一種 β-內醯胺抗生素（β-lactam antibiotic），屬於羧基青黴素（carboxypenicillin）。Carbenicillin 會與細菌的青黴素結合蛋白（penicillin-binding proteins， PBPs）結合，抑制轉肽酶（transpeptidase）活性，使肽聚醣（peptidoglycan）無法交聯。最後細菌因為細胞壁不完整，在滲透壓壓力下破裂而死亡。
Reference(s):
1. Sainsbury S et al. (2011). Crystal structures of penicillin-binding protein 3 from Pseudomonas aeruginosa: comparison of native and antibiotic-bound forms. J Mol Biol.
2. Ishii Y et al. (1995). Cloning and sequence of the gene encoding a cefotaxime-hydrolyzing class A beta-lactamase isolated from Escherichia coli. Antimicrob Agents Chemother.
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