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Carteolol

卡替洛爾

Mechanism of action:

Carteolol 是一種非選擇性 β-腎上腺素受體阻斷劑（non-selective β-adrenergic blocker）。對於眼部作用，carteolol 會阻斷睫狀體（ciliary body）的 β₂ 受體，抑制房水生成；同時阻斷 β₁ 受體，降低 β 受體介導的房水生成相關訊號。對於心血管作用，能阻斷心臟 β₁ 受體，降低心跳速率與收縮力，導致降低血壓與心肌耗氧量；另外也阻斷血管與支氣管 β₂ 受體，引起輕度支氣管收縮。

​Reference(s):

1. El-Kamel A et al. (2006). Environmentally responsive ophthalmic gel formulation of carteolol hydrochloride. Drug Deliv. 


2. Kuwahara K et al. (2005). Carteolol hydrochloride protects human corneal epithelial cells from UVB-induced damage in vitro. Cornea. 


3. Trinquand C et al. (2003). Efficacy and safety of long-acting carteolol 1% once daily: a double-masked, randomized study. J Fr Ophtalmol.

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