top of page
< Back

Cefepime

頭孢吡肟

Mechanism of action:

Cefepime 是一種第四代頭孢菌素抗生素（fourth-generation cephalosporin antibiotic）。Cefepime 的 β-內醯胺（β-lactam）環可與細菌的青黴素結合蛋白（penicillin-binding proteins，PBPs）結合，抑制其轉肽酶（transpeptidase）活性，使肽聚醣（peptidoglycan）鏈無法交聯，最後細胞壁結構脆弱，因滲透壓而讓細菌裂解死亡。

​Reference(s):

1. Chapman TM et al. (2003). Cefepime: a review of its use in the management of hospitalized patients with pneumonia. Am J Respir Med. 


2. Barbhaiya RH et al. (1991). Disposition of the cephalosporin cefepime in normal and renally impaired subjects. Drug Metab Dispos. 


3. Ortega AJ et al. (2021). Cefepime-induced encephalopathy in a high-risk patient with renal insufficiency and cirrhosis. Cureus.

bottom of page