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Cefixime

頭孢克肟

Mechanism of action:

Cefixime 是一種第三代口服頭孢菌素抗生素（third-generation cephalosporin antibiotic）。Cefixime 的 β-內醯胺（β-lactam）環可與細菌的青黴素結合蛋白（penicillin-binding proteins，PBPs）結合，抑制其轉肽酶（transpeptidase）活性，使肽聚醣（peptidoglycan）鏈無法交聯，最後細胞壁結構脆弱，因滲透壓而讓細菌裂解死亡。

​Reference(s):

1. McMillan A et al. (2007). The treatment of pharyngeal gonorrhoea with a single oral dose of cefixime. Int J STD AIDS. 


2. Adam D et al. (1995). 5-day cefixime therapy for bacterial pharyngitis and/or tonsillitis: comparison with 10-day penicillin V therapy. Infection.

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