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Cefoperazone

頭孢哌酮

Mechanism of action:

Cefoperazone 是一種第三代頭孢菌素抗生素（third-generation cephalosporin antibiotic）。Cefoperazone 的 β-內醯胺（β-lactam）環可與細菌的青黴素結合蛋白（penicillin-binding proteins，PBPs）結合，抑制其轉肽酶（transpeptidase）活性，使肽聚醣（peptidoglycan）鏈無法交聯，最後細胞壁結構脆弱，因滲透壓而讓細菌裂解死亡。

​Reference(s):

1. Jones RN et al. (1983). Cefoperazone: a review of its antimicrobial spectrum, beta-lactamase stability, enzyme inhibition, and other in vitro characteristics. Rev Infect Dis. 


2. TITCK. (n.d.). Product Information: Cefobid (cefoperazone sodium) for intramuscular/intravenous injection.

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