top of page
< Back

Cefoxitin

頭孢西丁

Mechanism of action:

Cefoxitin 是一種第二代頭孢菌素抗生素（second-generation cephalosporin antibiotic），亦常被歸類為頭黴素類（cephamycin）。Cefoxitin 的 β-內醯胺（β-lactam）環可與細菌的青黴素結合蛋白（penicillin-binding proteins，PBPs）結合，抑制其轉肽酶（transpeptidase）活性，使肽聚醣（peptidoglycan）鏈無法交聯，最後細胞壁結構脆弱，因滲透壓而讓細菌裂解死亡。

​Reference(s):

Matsuhashi M et al. (1978). Enzymatic studies on the mechanism of action of cefoxitin: Correlation between the affinities of cefoxitin to penicillin-binding proteins and its rates of inhibition of the respective penicillin-sensitive reactions in E. coli. J Antibiot (Tokyo).

bottom of page