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Ceftaroline

頭孢洛林

Mechanism of action:

Ceftaroline 是一種第五代頭孢菌素抗生素（advanced-generation cephalosporin）。Ceftaroline 的 β-內醯胺（β-lactam）環可與細菌的青黴素結合蛋白（penicillin-binding proteins，PBPs）結合，抑制其轉肽酶（transpeptidase）活性，使肽聚醣（peptidoglycan）鏈無法交聯，最後細胞壁結構脆弱，因滲透壓而讓細菌裂解死亡。

​Reference(s):

1. Steed ME et al. (2010). Ceftaroline: a new cephalosporin with activity against resistant gram-positive pathogens. Pharmacotherapy. 


2. Kollef MH et al. (2009). New antimicrobial agents for methicillin-resistant Staphylococcus aureus. Crit Care Resusc.

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