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The Sound of Evolution
Ceftobiprole
頭孢比普
Mechanism of action:
Ceftobiprole 是一種第五代頭孢菌素抗生素（advanced-generation cephalosporin）。Ceftobiprole 的 β-內醯胺（β-lactam）環可與細菌的青黴素結合蛋白（penicillin-binding proteins，PBPs）結合，抑制其轉肽酶（transpeptidase）活性，使肽聚醣（peptidoglycan）鏈無法交聯，最後細胞壁結構脆弱，因滲透壓而讓細菌裂解死亡。
Reference(s):
1. Davies TA et al. (2007). Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. Antimicrob Agents Chemother.
2. Noel GJ et al. (2007). Clinical profile of ceftobiprole, a novel beta-lactam antibiotic. Clin Microbiol Infect.
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