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Ceftriaxone

頭孢曲松

Mechanism of action:

Ceftriaxone 是一種第三代頭孢菌素抗生素（third-generation cephalosporin antibiotic）。Ceftriaxone 的 β-內醯胺（β-lactam）環可與細菌的青黴素結合蛋白（penicillin-binding proteins，PBPs）結合，抑制其轉肽酶（transpeptidase）活性，使肽聚醣（peptidoglycan）鏈無法交聯，最後細胞壁結構脆弱，因滲透壓而讓細菌裂解死亡。

​Reference(s):

1. Richards DM et al. (1984). Ceftriaxone: A review of its antibacterial activity, pharmacological properties and therapeutic use. Drugs. 


2. Park HZ et al. (1991). Ceftriaxone-associated gallbladder sludge: Identification of calcium-ceftriaxone salt as a major component of gallbladder precipitate. Gastroenterology.

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