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Cephalexin

頭孢氨苄

Mechanism of action:

Cephalexin 是一種第一代口服頭孢菌素抗生素（first-generation cephalosporin antibiotic）。Cephalexin 的 β-內醯胺（β-lactam）環可與細菌的青黴素結合蛋白（penicillin-binding proteins，PBPs）結合，抑制其轉肽酶（transpeptidase）活性，使肽聚醣（peptidoglycan）鏈無法交聯，最後細胞壁結構脆弱，因滲透壓而讓細菌破裂死亡。

​Reference(s):

1. Thornhill TS et al. (1969). In vitro antimicrobial activity and human pharmacology of cephalexin, a new orally absorbed cephalosporin C antibiotic. Appl Microbiol. 


2. Sullivan HR et al. (1969). Metabolism of cephalexin-14C in mice and in rats. J Antibiot (Tokyo).

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