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Chloramphenicol

氯黴素

Mechanism of action:

Chloramphenicol 會與細菌核糖體的 50S 亞基的 23S rRNA 結合，阻斷肽鏈轉移反應（peptidyl transferase activity），也阻止胺基酸之間形成肽鍵，導致蛋白質合成停止。

​Reference(s):

1. Bhutta ZA et al. (1992). Chloramphenicol clearance in typhoid fever: implications for therapy. Indian J Pediatr. 


2. Wali SS et al. (1979). Single injection treatment of meningococcal meningitis: Long-acting chloramphenicol. Trans R Soc Trop Med Hyg. 


3. Puddicombe JB et al. (1984). A field trial of a single intramuscular injection of long-acting chloramphenicol in the treatment of meningococcal meningitis. Trans R Soc Trop Med Hyg.

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