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Chlordiazepoxide

氯氮䓬

Mechanism of action:

Chlordiazepoxide 是一種苯二氮平類（long-acting benzodiazepine）衍生物。Chlordiazepoxide 結合於 GABA_A 受體上的苯二氮平結合位點，增強 GABA_A 的作用效率，提高 GABA 結合配體後氯離子（Cl⁻）通道開啟頻率，使神經細胞膜超極化（hyperpolarization），降低神經興奮性，來達到鎮靜、抗焦慮、肌肉鬆弛與抗痙攣。

​Reference(s):

1. Skerritt JH et al. (1983). Enhancement of GABA binding by benzodiazepines and related anxiolytics. Eur J Pharmacol. 


2. Oishi R et al. (1986). Diazepam-induced decrease in histamine turnover in mouse brain. Eur J Pharmacol. 


3. Earley JV et al. (1979). Quinazolines and 1,4-benzodiazepines: Haptens useful in benzodiazepine immunoassay development. J Pharm Sci.

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