The Sound of Evolution
Chlorthalidone
氯噻酮
Mechanism of action:
Chlorthalidone 是一種噻𠯤類利尿劑（thiazide-like diuretic）。Chlorthalidone 主要作用於腎臟遠曲小管，抑制 Na⁺/Cl⁻ 共運輸蛋白（Na⁺/Cl⁻ cotransporter），減少鈉與氯離子重新吸收，增加鈉、氯、水的排泄量。
Reference(s):
1. Wright JM et al. (1999). Systematic review of antihypertensive therapies: does the evidence assist in choosing a first-line drug? CMAJ.
2. Siragy HM et al. (2003). Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitors or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Curr Hypertens Rep.
3. ALLHAT Collaborative Research Group. (2000). Major cardiovascular events in hypertensive patients randomized to doxazosin vs chlorthalidone: the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). JAMA.