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Choriogonadotropin alfa

阿法絨毛膜促性腺激素

Mechanism of action:

Choriogonadotropin alfa 是重組的人類絨毛膜促性腺激素(recombinant human chorionic gonadotropin,rhCG),能模擬黃體成長激素(luteinizing hormone,LH) 的作用。在卵巢的顆粒細胞(granulosa cell)與卵泡膜細胞(theca cell)上, choriogonadotropin alfa 會透過與黃體成長激素/絨毛膜促性腺激素受體(LH/CG receptor)結合,啟動與黃體成長激素相同的訊號傳導途徑,刺激腺苷酸環化酶(adenylyl cyclase),增加 cAMP,促進卵泡成熟與排卵、黃體形成與孕酮(progesterone)分泌增加。

​Reference(s):

1. Kayisli UA et al. (2003). Human chorionic gonadotropin contributes to maternal immunotolerance and endometrial apoptosis by regulating Fas–Fas ligand system. J Immunol. 


2. Askling J et al. (1999). Sickness in pregnancy and sex of child. Lancet.

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