top of page
< Back

Cinoxacin

西諾沙星

Mechanism of action:

Cinoxacin 是第一代喹諾酮類抗生素（first-generation quinolone antibiotic）。Cinoxacin 會與 DNA 旋轉酶（DNA gyrase，細菌的拓撲異構酶 II，topoisomerase II）-DNA 複合體結合，使 DNA 旋轉酶產生的斷裂 DNA 無法被重新接合，導致 DNA 雙股斷裂累積，DNA 複製與轉錄停止，最終細菌死亡。

​Reference(s):

1. Jariyawat S et al. (1999). The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1. J Pharmacol Exp Ther. 


2. Drlica K et al. (1997). DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev.

bottom of page