top of page
The Sound of Evolution
Cisatracurium
順-阿屈庫銨
Mechanism of action:
Cisatracurium 是一種非去極化型神經肌肉阻斷劑（non-depolarizing neuromuscular blocker），屬於芐基異喹啉鎓（benzylisoquinolinium）類分子。Cisatracurium 在運動終板（motor end-plate）的菸鹼型乙醯膽鹼受體（nicotinic acetylcholine receptor）上與乙醯膽鹼（acetylcholine）競爭結合位點，阻止該受體活化，進而阻止鈉離子通道開啟，導致無法產生終板電位（end-plate potential），肌肉因此無法去極化與收縮。
Reference(s):
1. Szakmany T et al. (2015). Use of cisatracurium in critical care: a review of the literature. Minerva Anestesiol.
2. Bryson HM et al. (1997). Cisatracurium besilate: A review of its pharmacology and clinical potential in anaesthetic practice. Drugs.
3. Kisor DF et al. (1999). Clinical pharmacokinetics of cisatracurium besilate. Clin Pharmacokinet.
bottom of page