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Citalopram

西酞普蘭

Mechanism of action:

Citalopram 是一種選擇性血清素回收抑制劑（selective serotonin reuptake inhibitor）。在中樞神經突觸間，血清素（serotonin，5-hydroxytryptamine，5-HT）釋放至突觸間隙後，通常經過一段時間會被突觸前神經元的血清素轉運體（serotonin transporter）回收再利用。Citalopram 會抑制血清素轉運體的功能，讓突觸間血清素濃度無法下降，延長 5-HT 在受體上的作用時間，能減少焦慮與憂鬱症狀。

​Reference(s):

1. Sindrup SH et al. (1992). The selective serotonin reuptake inhibitor citalopram relieves the symptoms of diabetic neuropathy. Clin Pharmacol Ther. 


2. Atmaca M et al. (2002). The efficacy of citalopram in the treatment of premature ejaculation: a placebo-controlled study. Int J Impot Res. 


3. Andersen G et al. (1993). Citalopram for post-stroke pathological crying. Lancet.

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