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The Sound of Evolution
Clobazam
氯巴占
Mechanism of action:
Clobazam 是一種苯二氮平類（benzodiazepine）衍生物。其主要作用機制為增強中樞神經系統中 GABA_A 受體的抑制性傳導作用。Clobazam 能結合於 GABA_A 受體上的苯二氮平結合位點，提升受體對 GABA 的親和力。提高 GABA 結合後，clobazam 會使氯離子通道開啟頻率增加，導致較多氯離子流入神經元，使細胞膜產生超極化（hyperpolarization），降低神經元動作電位傳導機率，最終產生抗痙攣、鎮靜、抗焦慮。
Reference(s):
1. Freche C et al. (1975). Study of an anxiolytic, clobazam, in otorhinolaryngology in psychosomatic pharyngeal manifestations. Sem Hop Ther.
2. Canadian Clobazam Cooperative Group. (1991). Clobazam in treatment of refractory epilepsy: the Canadian experience. A retrospective study. Epilepsia.
3. Wildin JD et al. (1990). Respiratory and sedative effects of clobazam and clonazepam in volunteers. Br J Clin Pharmacol.
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