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Cloxacillin

氯唑西林

Mechanism of action:

Cloxacillin 是一種屬於 β-內醯胺類抗生素（β-lactam antibiotic）。Cloxacillin 的 β-內醯胺（β-lactam）環可與細菌的青黴素結合蛋白（penicillin-binding proteins，PBPs）結合，抑制其轉肽酶（transpeptidase）活性，使肽聚醣（peptidoglycan）鏈無法交聯，最後細胞壁結構脆弱，因滲透壓而讓細菌破裂死亡。

​Reference(s):

1. Lalanne S et al. (2020). Differential interactions of the beta-lactam cloxacillin with human renal organic anion transporters (OATs). Fundam Clin Pharmacol. 


2. Thijssen HH et al. (1976). Active metabolites of isoxazolylpenicillins in humans. Antimicrob Agents Chemother. 


3. Bratlid D et al. (1976). Displacement of albumin-bound antimicrobial agents by bilirubin. Pharmacology.

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