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The Sound of Evolution
Colesevelam
考來維侖
Mechanism of action:
Colesevelam 屬於膽汁酸螯合樹脂類（bile acid sequestrant resin）。Colesevelam 在腸道中不被吸收，而是可與膽汁酸（bile acids）形成不可吸收的複合物，阻止膽汁酸在迴腸被重新吸收，隨著糞便排出。結果導致膽汁酸排出量增加，肝臟內膽汁酸濃度下降。為了合成新的膽汁酸，肝細胞會增加低密度脂蛋白受體（low-density lipoprotein (LDL) receptor）的表達，加強對血液中低密度脂蛋白（LDL）的攝取與分解。最終導致血漿中的低密度脂蛋白膽固醇（LDL-C）濃度下降。
Reference(s):
1. Levy P et al. (2010). The potential role of colesevelam in the management of prediabetes and type 2 diabetes mellitus. Postgrad Med.
2. Staels B et al. (2009). A review of bile acid sequestrants: potential mechanism(s) for glucose-lowering effects in type 2 diabetes mellitus. Postgrad Med.
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